Stewart J, Courtney D F, Fowler B, Ramsden C H, Kester R C
J Antimicrob Chemother. 1984 Apr;13(4):377-82. doi: 10.1093/jac/13.4.377.
After pre-operative administration of 1 g, latamoxef disodium (moxalactam) levels were measured in peripheral venous blood, skeletal muscle and subcutaneous fat sampled from 29 patients during either arterial reconstruction or amputation undertaken for arterial occlusive disease. Tissue samples were taken from both proximal and distal levels in the amputated limbs. Levels of latamoxef disodium were above the minimum inhibitory concentration required for most commonly encountered Gram-positive and Gram-negative organisms. No patients developed toxicity or superficial wound infection but there was one vascular graft infection by Candida albicans. It has been shown that latamoxef disodium penetrates rapidly into the subcutaneous fat and skeletal muscle of relatively ischaemic limbs, achieving levels inhibitory to many common pathogens.
在对29例因动脉闭塞性疾病接受动脉重建或截肢手术的患者术前给予1克拉氧头孢钠（羟羧氧酰胺菌素）后，采集外周静脉血、骨骼肌和皮下脂肪样本，测定其中拉氧头孢钠的含量。在截肢肢体的近端和远端均采集了组织样本。拉氧头孢钠的含量高于大多数常见革兰氏阳性菌和革兰氏阴性菌所需的最低抑菌浓度。没有患者出现毒性反应或浅表伤口感染，但有1例发生了白色念珠菌引起的血管移植物感染。研究表明，拉氧头孢钠能迅速渗透到相对缺血肢体的皮下脂肪和骨骼肌中，达到对许多常见病原体有抑制作用的水平。
