Kester R C, Ramsden C H, Matharu S S
Curr Med Res Opin. 1979;6(1):44-9. doi: 10.1185/03007997909109397.
Seventeen patients with atherosclerotic disease, who were undergoing arterial reconstruction or amputation of the lower limb, had 2 g cephazolin injected per-operatively in two equal doses by intramuscular and intravenous routes. Samples of subcutaneous fat and skeletal muscle from the ischaemic leg, and serum were collected during the operation for assay of cephazolin content. The mean cephazolin levels in the serum, skeletal muscle and subcutaneous fat were found to be well above the minimum inhibitory concentrations required for most important Gram-positive and Gram-negative pathogens.
17例患有动脉粥样硬化疾病且正在接受下肢动脉重建术或截肢手术的患者，术中通过肌肉注射和静脉注射两种途径，分两次等量给予2克头孢唑林。术中采集缺血腿部的皮下脂肪和骨骼肌样本以及血清，用于检测头孢唑林含量。结果发现，血清、骨骼肌和皮下脂肪中的头孢唑林平均水平远高于大多数重要革兰氏阳性和革兰氏阴性病原体所需的最低抑菌浓度。
