Holti G
Curr Med Res Opin. 1979;6(4):267-70. doi: 10.1185/03007997909109435.
A double-blind, placebo-controlled study was carried out in 10 hypertensive patients who were subject to frequent attacks of Raynaud's phenomenon and suffered from cold hands, to assess the peripheral vasoconstrictor effects of penbutolol. After a wash-out period of 2 weeks on placebo, patients received two 14-day treatment periods, in random order, with either 20 mg penbutolol twice daily or placebo separated by a second 2-week single-blind wash-out period on placebo. The results of digital blood flow measurements showed that penbutolol did not produce any additional vasoconstrictor effect on digital circulation. The significance of these findings is discussed.
对10名高血压患者进行了一项双盲、安慰剂对照研究，这些患者经常发作雷诺现象且双手冰凉，以评估喷布洛尔的外周血管收缩作用。在接受2周安慰剂洗脱期后，患者随机接受两个为期14天的治疗期，分别为每日两次服用20mg喷布洛尔或服用安慰剂，两个治疗期之间有一个为期2周的安慰剂单盲洗脱期。数字血流测量结果显示，喷布洛尔对指端循环未产生任何额外的血管收缩作用。本文讨论了这些发现的意义。
