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1
Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog.肽激素催产素及其脱氨基类似物环状部分的二级结构。
Proc Natl Acad Sci U S A. 1970 May;66(1):111-6. doi: 10.1073/pnas.66.1.111.
2
Proposed conformation of oxytocin in solution.溶液中催产素的推测构象。
Proc Natl Acad Sci U S A. 1971 May;68(5):956-8. doi: 10.1073/pnas.68.5.956.
3
Conformational studies on tocinamide and deaminotocinamide by 220 MHz nuclear magnetic resonance spectroscopy.通过220兆赫核磁共振光谱对托西酰胺和脱氨基托西酰胺进行构象研究。
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1470-4. doi: 10.1073/pnas.69.6.1470.
4
Deuterated oxytocins: the synthesis and biological properties of a crystalline analog of deamino-oxytocin deuterated in the 5-asparagine position.氘代催产素：5-天冬酰胺位置氘代的脱氨基催产素晶体类似物的合成及生物学特性
Proc Natl Acad Sci U S A. 1969 Sep;64(1):263-6. doi: 10.1073/pnas.64.1.263.
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Conformational studies on [Pro3, Gly4]-oxytocin in dimethyl sulfoxide by 1H nuclear magnetic resonance spectroscopy: evidence for a type II beta turn in the cyclic moiety.通过核磁共振氢谱对二甲基亚砜中[脯氨酸3，甘氨酸4] - 催产素的构象研究：环状部分存在II型β-转角的证据
Biochemistry. 1978 Oct 17;17(21):4443-54. doi: 10.1021/bi00614a014.
6
Biofunctional evaluation of a hydrogen bond linking the ring and tail beta-turns of oxytocin.催产素环与尾β-转角间氢键的生物功能评估
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3309-13. doi: 10.1073/pnas.76.7.3309.
7
Biofunctional evaluation of a hydrogen bond stabilizing the beta-turn in the acyclic part of oxytocin.对稳定催产素无环部分β-转角的氢键进行生物功能评估。
Int J Pept Protein Res. 1980 Jul;16(1):55-60. doi: 10.1111/j.1399-3011.1980.tb02934.x.
8
A ureido group containing analogue of oxytocin comprising eight amino acid residues.
J Med Chem. 1978 Mar;21(3):306-8. doi: 10.1021/jm00201a017.
9
Synthesis and pharmacological evaluation of an analogue of the peptide hormone oxytocin that contains a mimetic of an inverse gamma-turn.
J Med Chem. 2002 Jun 6;45(12):2512-9. doi: 10.1021/jm0110744.
10
Proton magnetic resonance study of peptide conformation: effect of trifluoroethanol on oxytocin and 8-lysine-vasopressin.肽构象的质子磁共振研究：三氟乙醇对催产素和8-赖氨酸加压素的影响。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1199-203. doi: 10.1073/pnas.70.4.1199.

引用本文的文献

1
Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy.通过核磁共振光谱法观察到的环脂肽a的构象。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1199-202. doi: 10.1073/pnas.68.6.1199.
2
Oxytocin solution structure changes upon protonation of the N-terminus in dimethyl sulfoxide.在二甲基亚砜中，催产素溶液结构在N端质子化时会发生变化。
J Biomol NMR. 1993 Nov;3(6):653-73. doi: 10.1007/BF00198370.
3
Proposed conformation of oxytocin in solution.溶液中催产素的推测构象。
Proc Natl Acad Sci U S A. 1971 May;68(5):956-8. doi: 10.1073/pnas.68.5.956.
4
Nuclear magnetic resonance spectrum of lysine-vasopressin and its structural implications.赖氨酸加压素的核磁共振谱及其结构意义。
Proc Natl Acad Sci U S A. 1971 May;68(5):1028-31. doi: 10.1073/pnas.68.5.1028.
5
NMR studies on the conformation of derivatives of the side chain of oxytocin: examples of cis-trans isomerism.催产素侧链衍生物构象的核磁共振研究：顺反异构的实例
Proc Natl Acad Sci U S A. 1971 Feb;68(2):450-3. doi: 10.1073/pnas.68.2.450.
6
Conformational studies on arginine vasopressin and arginine vasotocin by proton magnetic resonance spectroscopy.利用质子磁共振波谱对精氨酸加压素和精氨酸催产素进行构象研究。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4528-32. doi: 10.1073/pnas.71.11.4528.
7
Carbon-13 magnetic resonance evaluation of polypeptide secondary structure and correlation with proton magnetic resonance studies.多肽二级结构的碳-13磁共振评估及其与质子磁共振研究的相关性。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3265-9. doi: 10.1073/pnas.71.8.3265.
8
300-MHz nuclear magnetic resonance study of oxytocin aqueous solution: conformational implications.催产素水溶液的300兆赫核磁共振研究：构象意义
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3806-9. doi: 10.1073/pnas.70.12.3806.
9
Conformational studies of oxytocin, lysine vasopressin, arginine vasopressin, and arginine vasotocin by carbon-13 nuclear magnetic resonance spectroscopy.通过碳-13核磁共振光谱法对催产素、赖氨酸加压素、精氨酸加压素和精氨酸催产素进行的构象研究。
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2086-90. doi: 10.1073/pnas.70.7.2086.
10
Proton magnetic resonance study of peptide conformation: effect of trifluoroethanol on oxytocin and 8-lysine-vasopressin.肽构象的质子磁共振研究：三氟乙醇对催产素和8-赖氨酸加压素的影响。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1199-203. doi: 10.1073/pnas.70.4.1199.

本文引用的文献

1
Possible molecular models for gramicidin S and their relationship to present ideas of protein structure.短杆菌肽S可能的分子模型及其与当前蛋白质结构观点的关系。
Biochem J. 1957 Apr;65(4):752-6. doi: 10.1042/bj0650752.
2
5-Valine-oxytocin and 1-deamino-5-valine-oxytocin. Syntheses and some pharmacological properties.5-缬氨酸-催产素和1-脱氨基-5-缬氨酸-催产素。合成及某些药理学性质。
J Biol Chem. 1966 Dec 10;241(23):5500-3.
3
Deamino-oxytocin. Its isolation by partition chromatography on Sephadex and crystallization from water, and its biological activities.去氨基催产素。通过在葡聚糖凝胶上的分配色谱法进行分离以及从水中结晶得到的去氨基催产素及其生物活性。
J Biol Chem. 1965 Nov;240(11):4264-6.
4
Temperature dependence of amide proton chemical shifts: the secondary structures of gramicidin S and valinomycin.酰胺质子化学位移的温度依赖性：短杆菌肽S和缬氨霉素的二级结构
Biochem Biophys Res Commun. 1969 Jul 23;36(2):194-202. doi: 10.1016/0006-291x(69)90314-3.
5
Nuclear magnetic resonance study of the structure and interactions of actinomycin D: temperature and solvent effects on the N--H and NH2 groups.
Nature. 1969 Jul 19;223(5203):302-3. doi: 10.1038/223302a0.
6
The molecular structure and some transport properties of valinomycin.缬氨霉素的分子结构及一些转运特性。
Biochem Biophys Res Commun. 1969 May 22;35(4):512-8. doi: 10.1016/0006-291x(69)90376-3.
7
A sensitive hydroosmotic toad bladder assay. Affinity and intrinsic activity of neurohypophyseal peptides.一种灵敏的蟾蜍膀胱渗透试验。神经垂体肽的亲和力和内在活性。
J Gen Physiol. 1968 Sep;52(3):465-81. doi: 10.1085/jgp.52.3.465.
8
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.多肽和蛋白质的立体化学标准。V. 三个相连肽单元系统的构象
Biopolymers. 1968 Oct;6(10):1425-36. doi: 10.1002/bip.1968.360061006.
9
"Cross-beta" conformation in proteins.蛋白质中的“交叉β”构象
J Mol Biol. 1968 Mar 14;32(2):343-58. doi: 10.1016/0022-2836(68)90014-4.
10
Conformational studies of peptide systems. The rotational states of the NH--CH fragment of alanine dipeptides by nuclear magnetic resonance.
Tetrahedron. 1969 Feb;25(3):493-515. doi: 10.1016/s0040-4020(01)83261-0.

肽激素催产素及其脱氨基类似物环状部分的二级结构。

Secondary structure of the cyclic moiety of the peptide hormone oxytocin and its deamino analog.

作者信息

Urry D W, Ohnishi M, Walter R

出版信息

Proc Natl Acad Sci U S A. 1970 May;66(1):111-6. doi: 10.1073/pnas.66.1.111.

DOI:10.1073/pnas.66.1.111
PMID:5273889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC286095/
Abstract

The secondary structure of the cyclic moiety of oxytocin and deamino-oxytocin has been determined by nuclear magnetic resonance spectroscopy (220 MHz). Oxytocin, in a dimethylsulfoxide-methanol mixture, contains a beta-turn involving the sequence -L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-. Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component. An initial attempt has been made to relate conformational features of the hormonal peptides to their biological activity.

摘要

已通过核磁共振光谱法（220兆赫）确定了催产素和脱氨基催产素环状部分的二级结构。在二甲基亚砜 - 甲醇混合物中的催产素含有一个涉及-L-酪氨酰-L-异亮氨酰-L-谷氨酰胺基-L-天冬酰胺基序列的β-转角。脱氨基催产素除了含有β-转角外，还含有一个涉及酪氨酸残基的酰胺氢和天冬酰胺残基的肽羰基的氢键，导致环组分具有反平行β型构象。已初步尝试将这些激素肽的构象特征与其生物活性联系起来。