鲨鱼产生具有有限异质性的19S IgM抗体。
Production of 19S IgM antibodies with restricted heterogeneity from sharks.
作者信息
Clem L W, Leslie G A
出版信息
Proc Natl Acad Sci U S A. 1971 Jan;68(1):139-41. doi: 10.1073/pnas.68.1.139.
Abstract
Two of three nurse sharks, Ginglymostoma cirratum, immunized with streptococcal A-variant vaccine, produced over 7 mg/ml serum of 19S IgM antibody to the group-specific carbohydrate. The light chains of this specific antibody from one shark were separated into multiple bands by disc electrophoresis. The light chains from the other antibody-producing animal were much less heterogeneous and gave only one predominant band.
摘要
三只护士鲨（长须鲨）中的两只，用A群链球菌变异株疫苗免疫后，产生了超过7毫克/毫升血清的针对群特异性碳水化合物的19S IgM抗体。通过圆盘电泳，来自一条鲨鱼的这种特异性抗体的轻链被分离成多条带。来自另一只产生抗体动物的轻链异质性要小得多，只出现一条主要条带。
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