从超免疫兔中分离出的链球菌群特异性抗体的特性。
Characteristics of streptococcal group-specific antibody isolated from hyperimmune rabbits.
作者信息
Osterland C K, Miller E J, Karakawa W W, Krause R M
出版信息
J Exp Med. 1966 Apr 1;123(4):599-614. doi: 10.1084/jem.123.4.599.
Abstract
Intravenous immunization of New Zealand red rabbits with streptococcal group-specific bacterial vaccines yielded sera which possessed markedly elevated gamma-globulin. The sera of one rabbit immunized with Group A-variant vaccine possessed 55 mg/ml of gamma-globulin. The bulk of this gamma-globulin, identified as gamma(G)-globulin, was homogeneous by zone electrophoresis and of specificity directed against the Group A-variant carbohydrate antigen. L chains isolated from specific antibody obtained from an immune precipitate were distributed as a single band on starch gel electrophoresis, whereas the normal gamma-globulin traveled as a diffuse smear. These data suggest that the rabbit streptococcal Group A-variant antibodies possess a limited range of physicochemical properties and electrophoretic mobility compared to that generally observed for the normal complement of gamma-globulin.
摘要
用链球菌属特异性细菌疫苗对新西兰白兔进行静脉免疫后，所产生的血清中γ球蛋白显著升高。一只用A组变异疫苗免疫的兔子血清中γ球蛋白含量为55毫克/毫升。通过区带电泳鉴定，这些γ球蛋白中的大部分为γ（G）球蛋白，具有均一性，且对A组变异碳水化合物抗原有特异性。从免疫沉淀物中获得的特异性抗体分离出的轻链在淀粉凝胶电泳上呈单一条带分布，而正常γ球蛋白则呈弥散状。这些数据表明，与正常γ球蛋白补体通常观察到的情况相比，兔链球菌A组变异抗体具有有限的物理化学性质和电泳迁移率范围。
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