Garzón J, Fuentes J A, Del Rio J
Eur J Pharmacol. 1979 Nov 16;59(3-4):293-6. doi: 10.1016/0014-2999(79)90293-0.
Rats isolated at 16--18 days of age showed after 10--12 months a complex behavioural syndrome in which locomotor activity was markedly increased when compared to that of group-housed controls. The hyperactivity of the socially deprived animals was selectively blocked by clinically effective antidepressants but not by other classes of psychotropic drugs. The present animal model may be of value for the detection of new antidepressants and contribute to elucidate the aetiology of depression.
16至18日龄时被隔离饲养的大鼠，在10至12个月后出现了一种复杂的行为综合征，与群居对照组相比，其运动活动明显增加。社会剥夺动物的多动被临床有效的抗抑郁药选择性地阻断，但未被其他类精神药物阻断。目前的动物模型对于检测新型抗抑郁药可能有价值，并有助于阐明抑郁症的病因。
