Novis B H, Young G O, Bank S, Marks I N
Lancet. 1975 Oct 18;2(7938):748-9. doi: 10.1016/s0140-6736(75)90728-x.
110 patients with proven chronic pancreatitis have been studied to assess the prevalence of the various Pi phenotypes of alpha1-antitrypsin in this disease compared with a control group of 116 blood-donors. The phenotype PiMZ (including Mweak) was significantly more prevalent and PiMM significantly less so in the patients with pancreatitis. It is possible that a heterozygous deficiency of this protease inhibitor renders the pancreas more vulnerable to aetiological agents (e.g., alcohol).
对110例已确诊的慢性胰腺炎患者进行了研究，以评估与116名献血者组成的对照组相比，该疾病中α1-抗胰蛋白酶各种Pi表型的患病率。PiMZ表型（包括Mweak）在胰腺炎患者中显著更为常见，而PiMM则显著较少见。这种蛋白酶抑制剂的杂合性缺乏可能使胰腺更容易受到病因（如酒精）的影响。
