Narumoto J, Arima T, Kunishi K, Yasuhara T, Suwaki K, Shimomura H, Nagashima H
Gastroenterol Jpn. 1979 Dec;14(6):617-20. doi: 10.1007/BF02773721.
Circulating immune complexes were tested in the liver disease by measuring polyclonal rheumatoid factor (pRF) inhibition activity. The test is based on the inhibition of 125I-pRF binding to IgG-p-azobenzamidoethyl Sepharose 6B. Normal levels of the test were less than 23%. The inhibition activity in sera with liver disease was found to correlate with severity of the disease, as defined by histological criteria. There were correlations of the activity with serum gamma-globulin concentration, seropositivities for rheumatoid factor and hepatitis B antigen.
通过测量多克隆类风湿因子（pRF）抑制活性来检测肝病患者体内的循环免疫复合物。该检测基于对125I-pRF与IgG-对氨基苯甲酰胺基乙基琼脂糖6B结合的抑制作用。该检测的正常水平低于23%。发现肝病患者血清中的抑制活性与根据组织学标准定义的疾病严重程度相关。该活性与血清γ-球蛋白浓度、类风湿因子和乙肝抗原的血清阳性率相关。
