Palasciano G, Saunieres J F, Laugier R, Sarles H
Gut. 1979 Dec;20(12):1063-5. doi: 10.1136/gut.20.12.1063.
Pancreatic response to intravenous secretin GIH (1CU/kg) +CCK-PZ (3CHRU/kg) was investigated in European and North African normal subjects. The pancreatic responses were compared in two groups of 38 normal male adults and in two groups of nine normal nurslings (less than 1 year). Body weight and age were similar in the two adult groups and in the two nursling groups. The peaks of volume, electrolytes, and enzymes were determined in samples of duodenal aspirate after hormonal stimulation. In adult subjects the flow rate and electrolytes were not statistically different in the two groups, while enzyme outputs were lower in the North African group -73% for lipase (P less than 0.001), -54% for phospholipase (P less than 0.01), and -35% for chymotrypsin (P less than 0.05). On the other hand, in both groups of nursling subjects all parameters of pancreatic secretion were identical. The difference in the pattern of the pancreatic response to exogenous hormonal stimulation observed between the two groups of adult subjects could be related to genetic or acquired differences. The second hypothesis is, however, the most probable because the pancreatic secretion was similar in both groups of nursling subjects.
在欧洲和北非的正常受试者中，研究了胰腺对静脉注射促胰液素GIH（1 CU/kg）+胆囊收缩素-胰酶泌素（3 CHRU/kg）的反应。对两组38名正常成年男性和两组9名正常婴儿（小于1岁）的胰腺反应进行了比较。两个成年组和两个婴儿组的体重和年龄相似。在激素刺激后，测定十二指肠抽吸物样本中的体积、电解质和酶的峰值。在成年受试者中，两组的流速和电解质没有统计学差异，而北非组的酶输出较低——脂肪酶降低73%（P<0.001），磷脂酶降低54%（P<0.01），糜蛋白酶降低35%（P<0.05）。另一方面，在两组婴儿受试者中，胰腺分泌的所有参数都是相同 的。两组成年受试者对外源激素刺激的胰腺反应模式的差异可能与遗传或后天差异有关。然而，第二种假设最有可能，因为两组婴儿受试者的胰腺分泌相似。
