Rutgeerts P, Ghoos Y, Vantrappen G
Gut. 1979 Dec;20(12):1072-7. doi: 10.1136/gut.20.12.1072.
Bile acid studies were performed in patients with Crohn's disease, radiologically confined to the colon. The bile acid pool size of 10 patients with isolated Crohn's colitis was significantly lower than that of 10 normal control subjects (P less than 0.001) and of 10 ulcerative colitis patients (P less than 0.005). Measurements of 14C-excretion in breath and in 24 hours stool collections after the administration of 5 muCi 14C-glycocholate showed a normal 14C-excretion in breath and usually a markedly increased loss of 14C in the stool (greater than 7% of the dose). The simultaneous administration of 5 muCi 3H-polyethylene glycol MW 4000 (3H-PEG) as a marker indicated that the 14C/3H ratio in the patients with Crohn's colitis was significantly greater than in a control series of patients with diarrhoea not due to bile acid malabsorption. Studies on the composition of duodenal bile showed a significantly decreased concentration of deoxycholic acid in duodenal bile. These observations suggest bile acid malabsorption in patients with Crohn's disease apparently confined to the colon.
对克罗恩病患者进行了胆汁酸研究,这些患者经放射学检查病变仅局限于结肠。10例孤立性克罗恩结肠炎患者的胆汁酸池大小显著低于10名正常对照受试者(P<0.001)以及10例溃疡性结肠炎患者(P<0.005)。在给予5μCi 14C-甘氨胆酸盐后,对呼出气体和24小时粪便中的14C排泄进行测量,结果显示呼出气体中的14C排泄正常,而粪便中的14C损失通常显著增加(超过剂量的7%)。同时给予5μCi 3H-聚乙二醇MW 4000(3H-PEG)作为标记物,结果表明克罗恩结肠炎患者的14C/3H比值显著高于一组非胆汁酸吸收不良所致腹泻的对照患者。对十二指肠胆汁成分的研究显示十二指肠胆汁中脱氧胆酸的浓度显著降低。这些观察结果提示,克罗恩病患者存在胆汁酸吸收不良,且病变显然仅局限于结肠。