单纯性克罗恩病中的胆汁酸研究。
Bile acid studies in uncomplicated Crohn's disease.
作者信息
Vantrappen G, Ghoos Y, Rutgeerts P, Janssens J
出版信息
Gut. 1977 Sep;18(9):730-5. doi: 10.1136/gut.18.9.730.
Abstract
The pool size and composition of bile acids were studied in 13 unoperated patients with uncomplicated Crohn's disease; 10 patients with ulcerative colitis, and 10 normal subjects. Many patients with Crohn's disease had in their bile a significantly increased amount of ursodeoxycholic acid. The bile acid pool size was significantly decreased and the ratio of glycine to taurine conjugates was significantly increased in the Crohn's disease patients. The reduction in bile acid pool size was related to the activity of the disease. The disorders of bile acid metabolism suggest that the intestinal involvement in Crohn's disease is much more extensive than can be demonstrated by careful radiological examinations.
摘要
对13例未经手术治疗的非复杂性克罗恩病患者、10例溃疡性结肠炎患者和10名正常受试者的胆汁酸池大小及成分进行了研究。许多克罗恩病患者胆汁中的熊去氧胆酸含量显著增加。克罗恩病患者的胆汁酸池大小显著减小，甘氨酸与牛磺酸结合物的比例显著增加。胆汁酸池大小的减小与疾病活动度有关。胆汁酸代谢紊乱表明，克罗恩病患者肠道受累程度比仔细的放射学检查所显示的要广泛得多。
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本文引用的文献
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