Sinclair I S, McCormick J S, Clark J G
J Hyg (Lond). 1971 Jun;69(2):201-7. doi: 10.1017/s0022172400021434.
The three heterologous anti-sera currently provided for tetanus prophylaxis have been compared with reference to the production of untoward reactions in 498 patients, and to the blood antitoxin concentrations produced in 76 patients. Equine serum, although giving rise to more reactions, was the only effective agent in terms of the levels and duration of serum antitoxin concentration produced. The local response to a test dose of any of the three sera is not a reliable guide to immediate or late general reactions.
目前用于破伤风预防的三种异种抗血清，已就498例患者的不良反应发生情况以及76例患者产生的血液抗毒素浓度进行了比较。马血清虽然引发的反应更多，但就所产生的血清抗毒素浓度水平和持续时间而言，是唯一有效的制剂。对这三种血清中任何一种的试验剂量的局部反应，都不是即时或迟发性全身反应的可靠指标。
