Ansari K A, Loch J
Neurology. 1975 Nov;25(11):1045-50. doi: 10.1212/wnl.25.11.1045.
Myelin basic protein was extracted from frontal lobe white matter obtained at autopsy from seven individuals ranging in age from 72 to 78 years. Qualitative and quantitative comparisons were made between basic protein from this group and that extracted from another group of individuals ranging in age from 45 to 65 years. The basic protein content of the older brains was considerably lower than that of the younger brains. Qualitative studies that included assay for encephalitogenic activity, disk gel electrophoresis at pH 4.3, and immunoprecipitation did not reveal any difference in the basic protein derived from the two age groups. Possible factors that may help explain the decreased basic protein content of the aged brain are discussed.
髓磷脂碱性蛋白是从7名年龄在72岁至78岁之间的个体尸检时获取的额叶白质中提取的。对该组的碱性蛋白与从另一组年龄在45岁至65岁之间的个体中提取的碱性蛋白进行了定性和定量比较。老年大脑的碱性蛋白含量明显低于年轻大脑。包括致脑炎活性测定、pH 4.3圆盘凝胶电泳和免疫沉淀在内的定性研究未发现两个年龄组来源的碱性蛋白有任何差异。讨论了可能有助于解释老年大脑碱性蛋白含量降低的因素。
