大鼠白细胞与同种异体解离皮肤细胞混合培养物中的DNA合成。
DNA synthesis in mixed cultures of rat leukocytes and allogeneic dissociated skin cells.
作者信息
Main R K, Cochrum K C, Jones M J, Kountz S L
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1165-8. doi: 10.1073/pnas.68.6.1165.
Abstract
A proliferative response (increased DNA synthesis measured by [(3)H]thymidine incorporation; maximum at the fifth day) occurs in mixed cultures of rat peripheral leukocytes and allogeneic dissociated skin cells. This response is allospecific and is greater than that occurring in mixed cultures of corresponding allogeneic leukocytes. This mitogenic property of dissociated skin cells is not shared with other nonlymphoid cell types, for example kidney cells. Cells from four isogenic rat strains have been studied; proliferative responses occurred in the mixed cell cultures only when cell donors differed by alleles at the Ag-B histocompatibility locus.
摘要
在大鼠外周白细胞与同种异体解离皮肤细胞的混合培养物中会出现增殖反应（通过[³H]胸腺嘧啶核苷掺入法测定DNA合成增加；在第五天达到最大值）。这种反应具有同种特异性，且比相应同种异体白细胞混合培养物中出现的反应更强。解离皮肤细胞的这种促有丝分裂特性其他非淋巴细胞类型（如肾细胞）并不具备。已经研究了来自四个同基因大鼠品系的细胞；只有当细胞供体在Ag - B组织相容性位点的等位基因不同时，混合细胞培养物中才会出现增殖反应。
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