糖皮质激素对小鼠腭裂相关RNA合成的抑制作用：一种模型
Glucocorticoid inhibition of RNA synthesis responsible for cleft palate in mice: a model.
作者信息
Zimmerman E F, Andrew F, Kalter H
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):779-85. doi: 10.1073/pnas.67.2.779.
Abstract
A study was undertaken to elucidate the molecular mechanisms by which glucocorticoids induce cleft palate in mice. It was hypothesized that a compound such as triamcinolone acetonide inhibits mRNA synthesis; that this results later in depressed protein synthesis; and that the latter is ultimately responsible for slowed palate formation and cleft palate. Support for the model derives from the fact that the palatine shelves rise and fuse 3-4 days after the most sensitive time of administration of steroid; RNA synthesis was markedly inhibited 6-24 hr after its administration; and coadministration of cycloheximide partially reversed the tendency toward cleft palate formation.
摘要
开展了一项研究以阐明糖皮质激素诱导小鼠腭裂的分子机制。据推测，诸如曲安奈德之类的化合物会抑制信使核糖核酸（mRNA）的合成；这随后会导致蛋白质合成减少；而后者最终会导致腭形成减缓及腭裂。该模型的依据是，在最敏感的类固醇给药时间后3 - 4天，腭板上升并融合；给药后6 - 24小时，核糖核酸（RNA）合成受到显著抑制；同时给予环己酰亚胺可部分逆转腭裂形成的趋势。
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