气液分配色谱法对尿液蒸气和呼气进行定量分析。
Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography.
作者信息
Pauling L, Robinson A B, Teranishi R, Cary P
出版信息
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2374-6. doi: 10.1073/pnas.68.10.2374.
Abstract
When a human being is placed for several days on a completely defined diet, consisting almost entirely of small molecules that are absorbed from the stomach into the blood, intestinal flora disappear because of lack of nutrition. By this technique, the composition of body fluids can be made constant (standard deviation about 10%) after a few days, permitting significant quantitative analyses to be performed. A method of temperature-programmed gas-liquid partition chromatography has been developed for this purpose. It permits the quantitative determination of about 250 substances in a sample of breath, and of about 280 substances in a sample of urine vapor. The technique should be useful in the application of the principles of orthomolecular medicine.
摘要
当一个人连续几天食用完全由小分子组成的特定饮食，这些小分子几乎全部从胃部吸收进入血液时，肠道菌群会因缺乏营养而消失。通过这种技术，几天后体液成分可保持恒定（标准差约为10%），从而能够进行重要的定量分析。为此已开发出一种程序升温气液分配色谱法。它可对呼出气体样本中的约250种物质以及尿液蒸汽样本中的约280种物质进行定量测定。该技术在正分子医学原理的应用中应会很有用。
相似文献
1
Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography.气液分配色谱法对尿液蒸气和呼气进行定量分析。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2374-6. doi: 10.1073/pnas.68.10.2374.
2
3
Thin-layer and gas-liquid chromatographic procedures for the determination of perazine and its metabolites in human body fluids.用于测定人体体液中奋乃静及其代谢物的薄层色谱法和气液色谱法。
Int J Clin Pharmacol Biopharm. 1977 Aug;15(8):366-72.
4
Partition coefficients of mercury (203Hg) vapor between air and biological fluids.
J Appl Toxicol. 1985 Oct;5(5):327-32. doi: 10.1002/jat.2550050512.
5
The determination of fluorochlorocarbons in air and body fluids.
J Pharm Pharmacol. 1973 Sep;25(9):718-22. doi: 10.1111/j.2042-7158.1973.tb10053.x.
6
Role of rebreathing in determination of the blood-breath ratio of expired ethanol.重复呼吸在测定呼出乙醇血-气比中的作用。
J Appl Physiol Respir Environ Exerc Physiol. 1983 Oct;55(4):1237-41. doi: 10.1152/jappl.1983.55.4.1237.
7
DETERMINATION OF ALCOHOLS IN BODY FLUIDS BY GAS-LIQUID CHROMATOGRAPHY.气相色谱法测定体液中的醇类物质
J Forensic Sci. 1965 Jan;10(1):73-6.
8
[Gas chromatographic analysis of sugars and sugar derivatives from non-dialysable components of biological fluids].
J Chromatogr. 1970 May 6;48(3):430-45. doi: 10.1016/s0021-9673(01)85577-1.
9
Henry's law constant, octanol-air partition coefficient and supercooled liquid vapor pressure of carbazole as a function of temperature: application to gas/particle partitioning in the atmosphere.咔唑的亨利定律常数、正辛醇-空气分配系数和过冷液体蒸气压随温度的变化：在大气气/粒分配中的应用
Chemosphere. 2006 Feb;62(7):1087-96. doi: 10.1016/j.chemosphere.2005.05.035. Epub 2005 Jul 12.
10
Simultaneous determination of amfepramon and its two major metabolites in biological fluids by gas liquid chromatography.采用气液色谱法同时测定生物流体中安非拉酮及其两种主要代谢物。
Arzneimittelforschung. 1986 Sep;36(9):1307-10.
引用本文的文献
1
Parallel Offline Breath Sampling for Cross-Validated Analysis of Volatile Organic Compound Metabolites.用于挥发性有机化合物代谢物交叉验证分析的并行离线呼气采样
Metabolomics. 2025 Sep 17;21(5):138. doi: 10.1007/s11306-025-02340-1.
2
Research hotspots and frontiers of application of mass spectrometry breath test in respiratory diseases.质谱呼气试验在呼吸系统疾病中的应用研究热点与前沿
Front Med (Lausanne). 2025 Aug 13;12:1618588. doi: 10.3389/fmed.2025.1618588. eCollection 2025.
3
Sensitive Detection of Specific Volatile Organic Compounds by Functionalized Transition Metal Dichalcogenide Monolayers.功能化过渡金属二硫属化物单层对特定挥发性有机化合物的灵敏检测
Langmuir. 2025 Aug 26;41(33):22455-22470. doi: 10.1021/acs.langmuir.5c02852. Epub 2025 Aug 12.
4
Diagnostic Potential of Volatile Organic Compounds in Detecting Insulin Resistance Among Taiwanese Women.挥发性有机化合物在检测台湾女性胰岛素抵抗中的诊断潜力
Diagnostics (Basel). 2025 Jul 18;15(14):1817. doi: 10.3390/diagnostics15141817.
5
Electronic-Nose Technology for Lung Cancer Detection: A Non-Invasive Diagnostic Revolution.用于肺癌检测的电子鼻技术：一场非侵入性诊断革命。
Lung. 2025 Jul 8;203(1):76. doi: 10.1007/s00408-025-00828-0.
6
Recent advances in cardiovascular disease research driven by metabolomics technologies in the context of systems biology.在系统生物学背景下，代谢组学技术推动心血管疾病研究取得的最新进展。
NPJ Metab Health Dis. 2024 Sep 23;2(1):25. doi: 10.1038/s44324-024-00028-z.
7
Estimating hypoxia-induced brain dysfunction and cognitive decline through exhaled breath monitoring.通过呼气监测评估缺氧诱导的脑功能障碍和认知衰退。
Respir Res. 2025 Jun 13;26(1):215. doi: 10.1186/s12931-025-03296-5.
8
Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis.生物基质中的挥发性有机化合物作为癌症诊断中的一种灵敏武器
Pharmaceuticals (Basel). 2025 Apr 27;18(5):638. doi: 10.3390/ph18050638.
9
Disclosing the development and focus of sequencing and omics studies in kidney neoplasm research.揭示肾脏肿瘤研究中测序和组学研究的发展与重点。
Discov Oncol. 2025 May 26;16(1):928. doi: 10.1007/s12672-025-02750-6.
10
The electronic nose in lung cancer diagnostics: a systematic review and meta-analysis.肺癌诊断中的电子鼻：系统评价与荟萃分析。
ERJ Open Res. 2025 May 19;11(3). doi: 10.1183/23120541.00723-2024. eCollection 2025 May.
本文引用的文献
1
Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease.
Science. 1968 Apr 19;160(3825):265-71. doi: 10.1126/science.160.3825.265.
2
Evolution and the need for ascorbic acid.进化与对抗坏血酸的需求。
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1643-8. doi: 10.1073/pnas.67.4.1643.
3
Individuality in vitamin C needs.维生素C需求的个体差异。
Proc Natl Acad Sci U S A. 1967 Jun;57(6):1638-41. doi: 10.1073/pnas.57.6.1638.
Zotero 插件