采用气液色谱法同时测定生物流体中安非拉酮及其两种主要代谢物。
Simultaneous determination of amfepramon and its two major metabolites in biological fluids by gas liquid chromatography.
作者信息
Dangor C M, Beckett A H, Veltman A M
出版信息
Arzneimittelforschung. 1986 Sep;36(9):1307-10.
PMID:3790180
Abstract
Sensitive and specific procedures based on gas liquid chromatography for the identification, separation and determination of amfepramon (diethylpropion) and its major metabolites ethylaminopropiophenone and diethylnorpseudoephedrine in human plasma, saliva and urine have been described. Acidification of the biological fluid samples has improved the stability of the compounds under conditions of storage.
摘要
已描述了基于气相色谱法的灵敏且特异的程序，用于在人血浆、唾液和尿液中鉴定、分离和测定安非拉酮（二乙丙胺苯丙酮）及其主要代谢物乙基氨基苯丙酮和二乙去甲伪麻黄碱。生物流体样品的酸化提高了化合物在储存条件下的稳定性。
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