Syrůcek L, Helcl J, Sejda J, Svandová E, Staninec M, Grantová H, Mertenová J, Mílek E, Mirovský J, Procházka J, Strauss J, Zdrazílek J
Bull World Health Organ. 1965;32(6):779-89.
The study reported in this article was conducted under the auspices of WHO as part of the Organization's programme on measles vaccination.In the spring of 1964, 416 children aged between 8 months and 3 years were inoculated with one or another of the following agents: Enders Edmonston B vaccine (alone or with gamma-globulin), Schwarz vaccine, Beckenham 20 vaccine, Milovanović vaccine, and a placebo.Seroconversion rates ranged from 91% to 100%, which indicates that the vaccines tested were highly immunogenic. The incidence of reactions was low, and from the clinical point of view acceptable. Clinical comparison of the reactions provoked by the different vaccines showed that the lowest rate was in the groups given Schwarz vaccine and Enders Edmonston B plus gamma-globulin, and the highest in the group given Beckenham 20 vaccine. However, the greater frequency of reactions observed with Beckenham 20 vaccine might have been due to the high dose given in the first stage of the trial.Complications were observed in 10 children, of whom four were in the placebo group. In three of the remaining cases a causal connexion with the vaccine could not be excluded with certainty.
本文报道的这项研究是在世卫组织的支持下开展的，作为该组织麻疹疫苗接种计划的一部分。1964年春，416名年龄在8个月至3岁之间的儿童接种了以下制剂中的一种：恩德斯·埃德蒙斯顿B疫苗（单独接种或与丙种球蛋白联合接种）、施瓦茨疫苗、贝肯纳姆20疫苗、米洛瓦诺维奇疫苗以及一种安慰剂。血清转化率在91%至100%之间，这表明所测试的疫苗具有高度免疫原性。反应发生率较低，从临床角度来看是可以接受的。对不同疫苗引发的反应进行临床比较显示，施瓦茨疫苗组以及恩德斯·埃德蒙斯顿B疫苗加丙种球蛋白组的反应率最低，而贝肯纳姆20疫苗组的反应率最高。然而，贝肯纳姆20疫苗观察到的反应频率较高可能是由于试验第一阶段给予的剂量较高。在10名儿童中观察到了并发症，其中4名在安慰剂组。在其余3例中，无法完全排除与疫苗的因果关系。
