Waitz J A, Ober R E, Meisenhelder J E, Thompson P E
Bull World Health Organ. 1965;33(4):537-46.
Tris (p-aminophenyl) carbonium (TAC) salts and certain antimonials have been shown to be more effective together against Schistosoma mansoni in mice than would be expected from the simple addition of their activities when given alone. Owing to the toxicity of antimonials, the therapeutic advantage of such synergistic effects would largely depend upon whether or not they occurred because the co-administration of TAC pamoate led to higher or more sustained levels of antimony in the blood or tissues. This study of the effect of TAC pamoate on the physiological disposition of (124)Sb was designed to give information on this important aspect.In general, co-administration of or pretreatment with TAC pamoate had no significant effect on the disposition of antimony. This indicates that the additive or synergistic effect of the two drugs against schistosomes is not due to higher or more sustained levels of antimony in the blood and tissues.
三（对氨基苯基）碳鎓（TAC）盐和某些锑剂已被证明，在小鼠体内共同对抗曼氏血吸虫时，其效果比单独给予时简单相加的预期效果更好。由于锑剂具有毒性，这种协同效应的治疗优势在很大程度上取决于它们的出现是否是因为同时给予TAC帕莫酸盐导致血液或组织中锑的水平更高或更持久。本研究旨在探讨TAC帕莫酸盐对（124）Sb生理分布的影响，以获取这一重要方面的信息。总体而言，同时给予或预先给予TAC帕莫酸盐对锑的分布没有显著影响。这表明这两种药物对血吸虫的相加或协同作用并非由于血液和组织中锑的水平更高或更持久。
