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现场试验伤寒疫苗的实验室毒性试验。

Laboratory toxicity test of field trial typhoid vaccines.

作者信息

Spaun J, Davidson I, Larsen S O

出版信息

Bull World Health Organ. 1965;33(5):673-9.

PMID:5295148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2475873/
Abstract

It is important for the control of vaccines to develop methods for testing their toxicity in the laboratory. Two typhoid vaccines that had given different rates of reactions among vaccinated persons in extensive field trials provided a unique opportunity for exploring the validity of the laboratory assessment of their toxicity. An elaborate design of a toxicity test based on weight changes in intraperitoneally vaccinated mice is described in this paper. The results of the laboratory test reflected the experience gained in field studies.

摘要

开发在实验室中检测疫苗毒性的方法对于疫苗控制至关重要。两种伤寒疫苗在广泛的现场试验中，在接种人群中产生了不同的反应率，这为探索实验室对其毒性评估的有效性提供了独特的机会。本文描述了一种基于腹腔接种小鼠体重变化的毒性试验的精心设计。实验室测试的结果反映了现场研究中获得的经验。

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引用本文的文献

1
Determination of endotoxicity in bacterial vaccines.细菌疫苗中内毒素的测定。
Appl Microbiol. 1973 Mar;25(3):403-7. doi: 10.1128/am.25.3.403-407.1973.

本文引用的文献

1
Is Universal Vaccination Against Pertussis Always Justified?百日咳普遍接种疫苗是否总是合理的？
Br Med J. 1960 Oct 22;2(5207):1184-6.
2
STUDIES ON THE INFLUENCE OF THE ROUTE OF IMMUNIZATION IN THE ACTIVE MOUSE PROTECTION TEST WITH INTRAPERITONEAL CHALLENGE FOR POTENCY ASSAY OF TYPHOID VACCINES.伤寒疫苗效价测定的主动小鼠保护试验中免疫途径对腹腔内攻毒影响的研究。
Bull World Health Organ. 1964;31(6):793-8.
3
INTERNATIONAL REFERENCE PREPARATIONS OF TYPHOID VACCINE. A REPORT ON INTERNATIONAL COLLABORATIVE LABORATORY STUDIES.伤寒疫苗国际参考制剂。国际协作实验室研究报告。
Bull World Health Organ. 1964;31(6):761-91.
4
CONTROLLED FIELD TRIAL IN BRITISH GUIANA SCHOOL CHILDREN OF HEAT-KILLED-PHENOLIZED AND ACETONE-KILLED LYOPHILIZED TYPHOID VACCINES.英属圭亚那学龄儿童中热酚灭活和丙酮冻干伤寒疫苗的对照现场试验。
Am J Hyg. 1964 Mar;79:196-206. doi: 10.1093/oxfordjournals.aje.a120376.

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