Sternberg M, De Grandpré P, Pelletier V, Carter M
Kidney Int. 1979 Sep;16(3):329-36. doi: 10.1038/ki.1979.135.
During nephrotoxic nephritis in the rat, an increased urinary excretion of glucosyl-galactosyl hydroxylysine and of galactosyl-hydroxylysine has been observed in the autologous phase of the disease. This due mainly to an elevation of the polypeptide-bound fraction of these hydroxylysyl glucosides with a molecular weight over 1,000 daltons. The levels of both urinary hydroxylysyl glucosides were correlated with proteinuria. Their increased excretion appears to originate in the lysed glomerular basement membrane. At the same stage of nephrotoxic nephritis, an increased glucosyl transferase activity could be demonstrated in the isolated glomeruli, correlated with albuminuria, attesting a higher turn-over of the disaccharide units of the glomerular basement membrane.
在大鼠肾毒性肾炎期间，在疾病的自身阶段观察到尿中葡萄糖基 - 半乳糖基羟赖氨酸和半乳糖基 - 羟赖氨酸的排泄增加。这主要是由于这些分子量超过1000道尔顿的羟赖氨酸糖苷的多肽结合部分升高所致。两种尿羟赖氨酸糖苷的水平均与蛋白尿相关。它们排泄的增加似乎源于裂解的肾小球基底膜。在肾毒性肾炎的同一阶段，在分离的肾小球中可证明葡萄糖基转移酶活性增加，与蛋白尿相关，证明肾小球基底膜二糖单位的周转率更高。
