Endreffy E, Túri S, Lászik Z, Bereczki C, Kása K
Department of Paediatrics, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Pediatr Nephrol. 1991 May;5(3):312-7. doi: 10.1007/BF00867490.
The effects of vitamin E on tissue oxidation, kidney function and morphology were studied in rats with nephrotoxic nephritis (NTN). Thirty-six nephritic animals received no treatment (group 1), while 36 were treated with vitamin E (group 2). Twenty-four hours after the administration of anti-glomerular basement membrane antibody, sulfhydryl-containing renal protein was significantly lower in group 1 than in group 2 (0.70 +/- 0.16 and 1.08 +/- 0.06 mmol/100 g kidney tissue, respectively), suggesting a free oxygen radical scavenging effect of vitamin E in group 2. The difference was similar on day 14. The creatinine clearance was significantly lower in group 1 than in group 2 on day 1 (40 +/- 30 and 204 +/- 60 microliter/min per 100 g body weight, respectively). The protein excretion was initially high in both groups, but a significant decrease was detected in group 2 relative to group 1 on day 14 (25 +/- 18 and 92 +/- 38 mg/24 h, respectively). The morphological changes were less severe in group 2. Vitamin E treatment did not alter any of the above values significantly in healthy animals. The release of oxygen free radicals in NTN might play an important role in the pathogenesis, which can be influenced by free radical scavengers through changes in kidney function and morphology.
在患有肾毒性肾炎（NTN）的大鼠中研究了维生素E对组织氧化、肾功能及形态的影响。36只患肾炎的动物未接受任何治疗（第1组），而另外36只接受了维生素E治疗（第2组）。给予抗肾小球基底膜抗体24小时后，第1组含巯基的肾蛋白显著低于第2组（分别为0.70±0.16和1.08±0.06 mmol/100 g肾组织），提示第2组中维生素E具有清除自由基的作用。第14天时差异类似。第1天时，第1组的肌酐清除率显著低于第2组（分别为每100 g体重40±30和204±60微升/分钟）。两组最初的蛋白排泄量均较高，但在第14天时，相对于第1组，第2组出现显著下降（分别为25±18和92±38 mg/24小时）。第2组的形态学变化较轻。在健康动物中，维生素E治疗未显著改变上述任何值。NTN中氧自由基的释放可能在发病机制中起重要作用，自由基清除剂可通过改变肾功能和形态对其产生影响。
