Sternberg M, Lagrue G
Ann Immunol (Paris). 1977 Jul-Oct;128C(4-5):905-8.
The disaccharide unit Glc-gal-hyl represents 6% of dry weight of the rat glomerular basement membrane. It has been shown to be a haptenic determinant of this membrane. It appears to be one of the targets of the lesions induced by nephrotoxic antibodies in the rat: the urinary excretion of Glc-gal-hyl (as well as of Gal-hyl and Hyl which may derive from Glc-gal-hyl by degradation) during the autologous phase of the rat glomerulonephritis is significantly increased. Simultaneously the biosynthesis of Glc-gal-hyl, as measured by the glomerular glucosyltransferase activity, is elevated by 72%.
二糖单元葡萄糖-半乳糖-羟赖氨酸占大鼠肾小球基底膜干重的6%。已证明它是该膜的半抗原决定簇。它似乎是大鼠中肾毒性抗体诱导损伤的靶点之一：在大鼠肾小球肾炎的自身期，葡萄糖-半乳糖-羟赖氨酸（以及可能由葡萄糖-半乳糖-羟赖氨酸降解产生的半乳糖-羟赖氨酸和羟赖氨酸）的尿排泄量显著增加。同时，通过肾小球葡萄糖基转移酶活性测定，葡萄糖-半乳糖-羟赖氨酸的生物合成增加了72%。
