Weigand K, Schopf R
Schweiz Med Wochenschr. 1981 Jun 6;111(23):859-63.
A charge heterogeneity of serum albumin can be demonstrated by special technics. This heterogeneity is due to the variation in the amount of free SH-groups and to binding of several substances. Electrophoretically, serum albumin can also separate into two distinct bands; this bisalbuminemia can be either transient or permanent. Binding of lactam antibiotics or limited proteolysis of albumin by pancreatic enzymes leads to transient form. For the permanent bisalbuminemias faster and slower migrating variants are known, the slower variants differing from normal serum albumin in the primary structure. The chemical basis for faster variants in unknown.
血清白蛋白的电荷异质性可用特殊技术加以证实。这种异质性是由于游离SH基团数量的变化以及几种物质的结合所致。在电泳中，血清白蛋白也可分离成两条明显的条带；这种双白蛋白血症可以是短暂的，也可以是永久性的。内酰胺类抗生素的结合或胰腺酶对白蛋白的有限蛋白水解会导致短暂形式。对于永久性双白蛋白血症，已知有迁移速度较快和较慢的变体，较慢的变体在一级结构上与正常血清白蛋白不同。迁移速度较快的变体的化学基础尚不清楚。
