霍乱带菌者的研究。
Studies on cholera carriers.
作者信息
Dizon J J, Fukumi H, Barua D, Valera J, Jayme F, Gomez F, Yamamoto S I, Wake A, Gomez C Z, Takahira Y, Paraan A, Rolda L, Alvero M, Abou-Gareeb A H, Kobari K, Azurin J C
出版信息
Bull World Health Organ. 1967;37(5):737-43.
Cholera carrier studies in the Philippines in 1964-66 showed a prevalence rate of 21.7% among household contacts of cholera patients, and 8.4% in occupants of houses next door to one where a cholera patient lived, as opposed to 0.34% in the general population. The duration of the carrier state among 19 household carriers isolated for examination varied from 5 to 19 days. The vibrio concentration in the stool of contact carriers was 10(2)-15(5) per gram, as compared with 10(6)-19(9) per ml of rice-water stool in cholera cases.The agglutinin titre increased with time for carriers, as it does for patients. It declined to a very low level 8-12 weeks after recovery, with the exception of one proved long-term carrier.The strains isolated from carriers were identical in all respects, including virulence in infant rabbits, with strains isolated from patients-except that 3 carrier strains were rough.
1964年至1966年在菲律宾进行的霍乱带菌者研究表明，霍乱患者的家庭接触者中带菌率为21.7%，在霍乱患者居住房屋隔壁的住户中带菌率为8.4%，而普通人群中的带菌率为0.34%。为进行检查而分离出的19名家庭带菌者的带菌状态持续时间从5天到19天不等。接触带菌者粪便中的弧菌浓度为每克10²至10⁵个，而霍乱病例的米泔水样粪便中每毫升为10⁶至10⁹个。带菌者的凝集素效价随时间升高，与患者情况相同。康复后8至12周，凝集素效价降至非常低的水平，但有一名经证实的长期带菌者除外。从带菌者分离出的菌株在各方面都与从患者分离出的菌株相同，包括对幼兔的毒力，只是有3株带菌者菌株是粗糙型的。
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