Johnston J H, Johnston R J, Simmons D A
Immunology. 1968 May;14(5):657-63.
rough mutants were divided into rough serotypes 1, 2, 3 and 4 by studying the homologous and heterologous reactions of their lipopolysaccharide components in a complement fixation test. The four serotypes corresponded with the classification of these lipopolysaccharides into four chemotypes on the basis of their qualitative sugar composition. As the molecular structures of the four chemotypes have been elucidated, the proposed classification of R-mutants was related to their chemical structure as well as their serological behaviour.
通过在补体结合试验中研究粗糙突变体脂多糖成分的同源和异源反应,将粗糙突变体分为粗糙血清型1、2、3和4。这四种血清型与基于其定性糖组成将这些脂多糖分类为四种化学型相对应。由于四种化学型的分子结构已被阐明,因此所提出的R突变体分类与其化学结构以及血清学行为有关。