主动脉弹性蛋白酶的分离、纯化及性质
Isolation, purification and properties of aortic elastase.
作者信息
Hornebeck W, Derouette J C, Robert L
出版信息
FEBS Lett. 1975 Oct 15;58(1):66-70. doi: 10.1016/0014-5793(75)80227-4.
PMID:5303
Abstract
An elastase from pig aorta has been partially purified and characterised; it exhibits immunological cross reaction with pig pancreatic elastase. Its proteolytic (k-elastin gel and polymeric elastin substrates) and esterolytic (N-succinoyl-trialanine paranitroanilide) activities as well as its degree of inhibition by serum protease inhibitors (alpha1-antitrypsin and alpha2-macro-globulin) differ sensibly from those of pancreatic elastase [14,16].
摘要
一种来自猪主动脉的弹性蛋白酶已被部分纯化并进行了特性鉴定；它与猪胰弹性蛋白酶表现出免疫交叉反应。其蛋白水解活性（以k-弹性蛋白凝胶和聚合弹性蛋白为底物）和酯水解活性（N-琥珀酰-丙氨酰-对硝基苯胺），以及血清蛋白酶抑制剂（α1-抗胰蛋白酶和α2-巨球蛋白）对它的抑制程度与胰弹性蛋白酶明显不同[14,16]。
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