重度烧伤患者血液中的血清弹性蛋白酶及其抑制剂
Serum elastase and its inhibitors in the blood of heavily burnt patients.
作者信息
Miskulin M, Moati F, Robert A M, Robert L, Monteil R, Guilbaud J
出版信息
J Clin Pathol. 1978 Sep;31(9):866-71. doi: 10.1136/jcp.31.9.866.
Abstract
Serum elastase and its inhibitors were determined in the sera of heavily burnt patients. Serum elastase levels were elevated at two to eight days after a severe burn-accident and returned towards normal values from the 10th day on. Both alpha1-antitrypsin and alpha2-macroglobulin levels were also elevated in the sera of heavily burnt patients. alpha1-Antitrypsin showed a parallel evolution to the elastase level but alpha2-macroglobulin followed a somewhat different time curve. Plasminogen and antithrombin were not elevated significantly. It is suggested that serum elastase may play a role in tissue degradation in burnt patients.
摘要
对重度烧伤患者的血清进行了弹性蛋白酶及其抑制剂的检测。在严重烧伤事故发生后的两到八天，血清弹性蛋白酶水平升高，从第10天起恢复至正常水平。重度烧伤患者血清中的α1抗胰蛋白酶和α2巨球蛋白水平也升高。α1抗胰蛋白酶与弹性蛋白酶水平呈平行变化，但α2巨球蛋白的时间曲线有所不同。纤溶酶原和抗凝血酶没有明显升高。提示血清弹性蛋白酶可能在烧伤患者的组织降解中起作用。
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