饰纹巨螯蟹毒素：突触体γ-氨基丁酸摄取的强效抑制剂。
Lophozozymus pictor toxin: a potent inhibitor of synaptosomal GABA uptake.
作者信息
Tan C H, Abkowitz S J
出版信息
Neurosci Lett. 1979 Oct;14(2-3):339-42. doi: 10.1016/0304-3940(79)96171-8.
PMID:530510
Abstract
A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a GABA concentration of 2 microM. The inhibition showed substrate competition.
摘要
从珊瑚礁蟹（多彩长眼蟹）中获得的一种部分纯化毒素，被发现是大鼠脑突触体中钠依赖性[14C] -γ-氨基丁酸（GABA）摄取的有效抑制剂。在外部钾离子存在的情况下，抑制作用增强。在GABA浓度为2微摩尔时，该毒素的半数抑制浓度（I50）值在10微克/毫升左右。这种抑制表现出底物竞争。
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