Sugár L, Bánóczy J
Bull World Health Organ. 1969;41(2):289-93.
Of the precancerous conditions of the mouth, leukoplakia is the most common, and it was considered likely that the long-term follow-up of patients would yield valuable information for the control and treatment of the condition.A study of the histories of 324 patients, in whom leukoplakia had been diagnosed sometime during the previous 23 years, showed that there was a relationship between smoking and the frequency of leukoplakia. Alcohol, mechanical irritants and electric potential difference in the mouth were also important etiological factors, particularly in combination. Many of the cases with mild symptoms improved when the etiological agent was removed.The cases were classified into groups according to whether there were signs of keratinized mucosa, verrucous proliferations or ulcerated white lesions. The more severe cases more frequently developed carcinomas and were treated by surgery.
在口腔癌前病变中，白斑最为常见，长期随访患者可能会获得有关该疾病控制和治疗的有价值信息。一项对324例患者病史的研究表明，这些患者在过去23年中的某个时间被诊断为白斑，研究发现吸烟与白斑的发生频率之间存在关联。酒精、机械刺激和口腔中的电位差也是重要的病因因素，尤其是多种因素共同作用时。当去除病因后，许多症状较轻的病例病情有所改善。根据是否存在角化黏膜体征、疣状增生或溃疡型白色病变，将病例进行分组。病情较严重的病例更易发展为癌症，需通过手术治疗。
