Gangadharan P, Paymaster J C
Br J Cancer. 1971 Dec;25(4):657-68. doi: 10.1038/bjc.1971.81.
An epidemiological study of 1504 cases of leukoplakia seen at the Tata Memorial Hospital, Bombay, indicates that the oral cavity was the site of the disease in 95% of the cases. The buccal mucosa was the commonest site affected in all religious communities of Western India except among Parsis. Parsis, a majority of whom are non-smokers and non-chewers of tobacco, had leukoplakia more often on the anterior 2/3rd tongue than on the buccal mucosa and this pattern persisted in the distribution of cancer also, whereas people from Gujarat more often smoke; in these the buccal mucosa was commonly affected with leukoplakia, but cancer was not so frequent in this site. Statistical computation of the risk of malignant transformation indicates that males have a 4·8 times higher risk of developing cancer when they have leukoplakia than the normal population, and the females have 7 times higher risk of developing cancer in the presence of leukoplakia. It was felt that leukoplakia not associated with smoking habits had a greater chance of malignant transformation.
一项对孟买塔塔纪念医院收治的1504例白斑病患者的流行病学研究表明，95%的病例病变部位在口腔。除帕西人外，印度西部所有宗教群体中，颊黏膜是最常受影响的部位。帕西人大多既不吸烟也不嚼烟草，他们患白斑病的部位更多是在舌前三分之二处而非颊黏膜，这种分布模式在癌症分布中也持续存在；而古吉拉特邦的人吸烟更为频繁，在这些人中，颊黏膜是白斑病的常见受累部位，但该部位患癌并不那么常见。恶性转化风险的统计计算表明，男性患白斑病时患癌风险比正常人群高4.8倍，女性患白斑病时患癌风险高7倍。研究认为，与吸烟习惯无关的白斑病发生恶性转化的可能性更大。
