Danforth H D, Ruff M D, Reid W M, Miller R L
Poult Sci. 1977 May;56(3):926-32. doi: 10.3382/ps.0560926.
Infections with single species of Eimeria acervulina, E. mivati, E. maxima, E. tenella, E. necatrix, and E. brunetti, and the six species mixed, were utilized in three separate battery experiments to evaluate the anticoccidial efficacy of various levels of salinomycin (AHR-3096), a fermentation product of a strain of Streptomyces albus. At the 60 to 100 p.p.m. treatment levels, this compound showed significant anticoccidial activity for all parameters studied (mortality, weight gain, feed conversion, dropping scores, and lesion scores). The mortality due to coccidiosis was reduced to 0.1% in the medicated infected birds. Some activity, as measured by weight gain, was seen in the lower levels of salinomycin medication (12.5 to 50 p.p.m.), but other parameters, including mortality and lesion scores, indicated less activity than that seen with the higher treatment levels. At 100 p.p.m., there was no apparent effect on the compound on bird performance in uninfected control birds. Salinomycin at the 100 p.p.m. treatment level was statistically as effective as 121 p.p.m. monensin (reference anticoccidial) in controlling coccidiosis.
分别用单一物种的堆型艾美耳球虫、米氏艾美耳球虫、巨型艾美耳球虫、柔嫩艾美耳球虫、毒害艾美耳球虫和布氏艾美耳球虫，以及这六种物种的混合感染，在三个独立的多笼实验中，评估了不同水平的盐霉素（AHR - 3096，一种白色链霉菌菌株的发酵产物）的抗球虫效果。在60至100 ppm的处理水平下，该化合物对所有研究参数（死亡率、体重增加、饲料转化率、粪便评分和病变评分）均显示出显著的抗球虫活性。用药感染禽类中，由球虫病导致的死亡率降至0.1%。在较低水平的盐霉素用药（12.5至50 ppm）中，通过体重增加可观察到一些活性，但包括死亡率和病变评分在内的其他参数显示，其活性低于较高处理水平时的活性。在100 ppm时，该化合物对未感染的对照禽类的生长性能没有明显影响。在控制球虫病方面，100 ppm处理水平的盐霉素在统计学上与121 ppm的莫能菌素（参考抗球虫药）效果相同。
