DiPalma J A, Perucca P J, Martin D F, Pierson W P, Meyer G W
Am J Gastroenterol. 1987 Apr;82(4):307-10.
There is relatively poor documentation of the effect of metoclopramide on the human esophageal body. We, therefore, studied several parameters of esophageal function in 19 normal volunteers both before and after 20 mg intravenous metoclopramide. Contraction amplitude, wave duration, velocity, and propagation time were increased after metoclopramide. These changes were more pronounced in the distal esophagus. At the most distal manometric recording level located 2 cm above the lower esophageal sphincter, contraction amplitude increased 39% (p less than 0.01) and duration increased 22.5% (p less than 0.01) after metoclopramide. We conclude that in normal subjects metoclopramide has an effect predominant in the distal body of the esophagus.
关于胃复安对人体食管体部作用的文献记载相对较少。因此，我们研究了19名正常志愿者在静脉注射20毫克胃复安前后的几项食管功能参数。注射胃复安后，收缩幅度、波持续时间、速度和传播时间均增加。这些变化在食管远端更为明显。在食管下括约肌上方2厘米处的最远端测压记录水平，注射胃复安后收缩幅度增加39%（p<0.01），持续时间增加22.5%（p<0.01）。我们得出结论，在正常受试者中，胃复安对食管远端体部的作用占主导。
