有机磷化合物的副作用：迟发性神经毒性。
Side effects of organophosphorus compounds: delayed neurotoxicity.
作者信息
Aldridge W N, Johnson M K
出版信息
Bull World Health Organ. 1971;44(1-3):259-63.
Abstract
Many organophosphorus compounds produce a chronic toxicity that has been classified as a dying-back process in which the long axons are particularly affected. Recent evidence indicates that an essential first step in the production of the lesion is the phosphorylation of a protein that is able to hydrolyse substrates such as phenyl phenylacetate. The esterase activity of the protein is inhibited by this phosphorylation, presumably at the active site. However, the toxic effect is related only to phosphorylation and not to loss of esterase activity.
摘要
许多有机磷化合物会产生一种慢性毒性，这种毒性已被归类为一种轴突退变过程，其中长轴突受到的影响尤为明显。最近的证据表明，产生这种损伤的一个关键的第一步是一种能够水解诸如苯乙酸苯酯等底物的蛋白质发生磷酸化。该蛋白质的酯酶活性被这种磷酸化抑制，推测是在活性位点。然而，毒性作用仅与磷酸化有关，而与酯酶活性的丧失无关。
相似文献
1
Side effects of organophosphorus compounds: delayed neurotoxicity.有机磷化合物的副作用：迟发性神经毒性。
Bull World Health Organ. 1971;44(1-3):259-63.
2
In vitro modifications of rat NTE and other esterases by chemicals which induce delayed neurotoxicity in vivo.体内可诱导迟发性神经毒性的化学物质对大鼠神经毒性酯酶及其他酯酶的体外修饰作用。
Vet Hum Toxicol. 1990 Oct;32(5):435-9.
3
4
In vivo inhibition of chicken brain acetylcholinesterase and neurotoxic esterase in relation to the delayed neurotoxicity of leptophos and cyanofenphos.体内抑制鸡脑乙酰胆碱酯酶和神经毒性酯酶与倍硫磷和苯腈磷的迟发性神经毒性的关系
J Environ Pathol Toxicol Oncol. 1986 Sep-Dec;7(1-2):211-24.
5
Effects of dosing regimens and routes of administration on organophosphorus ester induced delayed neurotoxicity.给药方案和给药途径对有机磷酸酯诱导的迟发性神经毒性的影响。
Neurotoxicology. 1983 Spring;4(1):139-46.
6
Organophosphorus and other inhibitors of brain 'neurotoxic esterase' and the development of delayed neurotoxicity in hens.有机磷及其他脑“神经毒性酯酶”抑制剂与母鸡迟发性神经毒性的发展
Biochem J. 1970 Dec;120(3):523-31. doi: 10.1042/bj1200523.
7
Delayed toxicity and delayed neurotoxicity of phosphonothioate and phosphonothioate esters.硫代磷酸酯和硫代磷酸酯的迟发性毒性和迟发性神经毒性。
J Toxicol Environ Health. 1981 Oct;8(4):619-27. doi: 10.1080/15287398109530096.
8
The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase.某些有机磷化合物的迟发性神经毒性作用。磷酸化位点作为酯酶的鉴定。
Biochem J. 1969 Oct;114(4):711-7. doi: 10.1042/bj1140711.
9
[Effects of organophosphate compounds with remote neurotoxicity].[具有迟发性神经毒性的有机磷化合物的作用]
Gig Sanit. 1988 Oct(10):83-4.
10
Neurotoxic potential of six organophosphorus compounds in adult hens.六种有机磷化合物对成年母鸡的神经毒性潜力
Vet Hum Toxicol. 1999 Oct;41(5):290-2.
引用本文的文献
1
The nature of the reaction of organophosphorus compounds and carbamates with esterases.有机磷化合物和氨基甲酸酯与酯酶的反应性质。
Bull World Health Organ. 1971;44(1-3):25-30.
2
Neurological manifestations of organophosphorous insecticide poisoning.有机磷杀虫剂中毒的神经学表现。
J Neurol Neurosurg Psychiatry. 1974 Jul;37(7):841-7. doi: 10.1136/jnnp.37.7.841.
3
Electrophysiological studies in acute organophosphate poisoning.急性有机磷中毒的电生理研究
J Neurol Neurosurg Psychiatry. 1987 Nov;50(11):1442-8. doi: 10.1136/jnnp.50.11.1442.
4
Organophosphorus esters causing delayed neurotoxic effects: mechanism of action and structure activity studies.引起迟发性神经毒性效应的有机磷酸酯：作用机制与构效关系研究
Arch Toxicol. 1975 Dec 18;34(4):259-88. doi: 10.1007/BF00353848.
5
Distal axonopathy: one common type of neurotoxic lesion.远端轴索性神经病：一种常见的神经毒性损伤类型。
Environ Health Perspect. 1978 Oct;26:97-105. doi: 10.1289/ehp.782697.
本文引用的文献
1
The relationship between the chemical structure and neurotoxicity of alkyl organophosphorus compounds.烷基有机磷化合物的化学结构与神经毒性之间的关系。
Br J Pharmacol Chemother. 1960 Jun;15(2):271-8. doi: 10.1111/j.1476-5381.1960.tb01243.x.
2
Paralytic and related effects of certain organic phosphorus compounds.某些有机磷化合物的麻痹及相关效应
AMA Arch Ind Health. 1956 Apr;13(4):326-30.
3
Further observations on the neurotoxicity of organophosphorus compounds.关于有机磷化合物神经毒性的进一步观察
Biochem Pharmacol. 1966 May;15(5):541-8. doi: 10.1016/0006-2952(66)90020-7.
4
Esterases and neurotoxicity of some organophosphorus compounds.某些有机磷化合物的酯酶与神经毒性
Biochem Pharmacol. 1966 May;15(5):549-54. doi: 10.1016/0006-2952(66)90021-9.
5
Studies on esterases in the chicken central nervous system.鸡中枢神经系统中酯酶的研究。
Biochem J. 1964 Jan;90(1):182-9. doi: 10.1042/bj0900182.
6
Delayed neurotoxic action of some organophosphorus compounds.某些有机磷化合物的迟发性神经毒性作用。
Br Med Bull. 1969 Sep;25(3):231-5. doi: 10.1093/oxfordjournals.bmb.a070709.
7
Acute toxicity of pesticides.农药的急性毒性
Toxicol Appl Pharmacol. 1969 May;14(3):515-34. doi: 10.1016/0041-008x(69)90013-1.
8
Protection by some carbamates against the delayed neurotoxic effects of di-isopropyl phosphorofluoridate.某些氨基甲酸盐对二异丙基氟磷酸酯延迟神经毒性作用的防护作用。
Nature. 1969 Jun 14;222(5198):1066-7. doi: 10.1038/2221066a0.
9
A phosphorylation site in brain and the delayed neurotoxic effect of some organophosphorus compounds.大脑中的一个磷酸化位点以及某些有机磷化合物的迟发性神经毒性作用。
Biochem J. 1969 Feb;111(4):487-95. doi: 10.1042/bj1110487.
10
Organophosphorus and other inhibitors of brain 'neurotoxic esterase' and the development of delayed neurotoxicity in hens.有机磷及其他脑“神经毒性酯酶”抑制剂与母鸡迟发性神经毒性的发展
Biochem J. 1970 Dec;120(3):523-31. doi: 10.1042/bj1200523.
Zotero 插件