Ryan G B, Grobéty J, Majno G
Am J Pathol. 1971 Oct;65(1):117-48.
THIS PAPER DESCRIBES AN EXPERIMENTAL MODEL OF PERITONEAL ADHESIONS, IN THE RAT, BASED ON TWO RELATIVELY MINOR ACCIDENTS THAT MAY OCCUR DURING ABDOMINAL SURGERY IN MAN: drying of the serosa, and bleeding. Drying alone had little effect; drying plus bleeding consistently produced adhesions to the dried area. Fresh blood alone produced adhesions between the three membranous structures [omentum and pelvic fat bodies (PFBs)]. The formation of persistent adhesions required whole blood. Preformed clots above a critical size induced adhesions even without previous serosal injury; they were usually captured by the omentum and PFBs. If all three membranous structures were excised, the clots caused visceral adhesions. The protective role of the omentum, its structure, and the mechanism of omental adhesions, are discussed. These findings are relevant to the pathogenesis of post-operative adhesions in man.
本文描述了一种大鼠腹膜粘连的实验模型，该模型基于人类腹部手术中可能发生的两种相对较小的意外情况：浆膜干燥和出血。单独干燥影响较小；干燥加出血会持续导致与干燥区域粘连。仅新鲜血液会导致三个膜性结构（大网膜和盆腔脂肪体）之间粘连。持续性粘连的形成需要全血。超过临界大小的预形成凝块即使没有先前的浆膜损伤也会导致粘连；它们通常会被大网膜和盆腔脂肪体捕获。如果切除所有三个膜性结构，凝块会导致内脏粘连。文中讨论了大网膜的保护作用、其结构以及大网膜粘连的机制。这些发现与人类术后粘连的发病机制相关。
