Rostad H, Vale J R, Nesthus I
Scand J Respir Dis. 1979 Aug;60(4):184-90.
A consecutive hospital series of 1 053 patients treated for lung cancer during the period 1962 through 1971 has been studied. Clinical symptoms were present more often in men than in women and in 42% symptoms had been noted more than 6 months prior to the diagnosis. Peripheral tumours gave less symptoms than central ones. Although in 22% of the patients the tumour was discovered on a chest film in the absence of relevant symptoms, 12% only had been detected by regular mass X-ray screening. More than 40% of the peripherally located tumours were clinically silent. Squamous cell and anaplastic small cell cancers were predominantly centrally located (80 and 90%, respectively) against 65% and 74% for adenocarcinomas and undifferentiated large cell tumours.
对1962年至1971年期间连续收治的1053例肺癌患者进行了研究。临床症状在男性中比在女性中更常见，42%的患者在诊断前6个月以上就已出现症状。周围型肿瘤的症状比中央型肿瘤少。虽然22%的患者在胸部X线片上发现肿瘤时并无相关症状，但只有12%是通过定期大规模X线筛查发现的。超过40%的周围型肿瘤在临床上没有症状。鳞状细胞癌和间变性小细胞癌主要位于中央（分别为80%和90%），而腺癌和未分化大细胞肿瘤分别为65%和74%。
