Bachmann M, Raeber E, Burckhardt D, Schwytzer F, Münch U, Kappenberger L, Nager F
Schweiz Med Wochenschr. 1979 Dec 8;109(47):1857-60.
18 patients with angina pectoris participated in a double blind trial with atenolol (100 mg and 200 mg once daily, or 100 mg twice daily) and propranolol (80 mg twice daily). The number of anginal attacks (NAP), the number of days free of pain (NAFT), consumption of sublingual nitroglycerin (NNT) and bicycle ergometry data (EFE) were recorded. Atenolol given in a dose of 100 g twice daily significantly reduced NAP and NNT as compared with the other dose schedules for atenolol and propranolol. There was, however, no difference between NAFT and EFE under any of the treatment schedules mentioned above. Only with 100 mg atenolol twice daily was it possible to reduce heart rate at rest and immediately after exercise testing, and also diastolic blood pressure (at rest, upright and after stress testing). In spite of the long plasma T 1/2 (= 24 hours) reported by others, atenolol given twice daily seems to be the most effective schedule. It is concluded that atenolol (100 mg twice daily) has a more potent anti-anginal effect than propranolol (80 mg twice daily). In addition, atenolol has the advantage of being cardioselective.
18例心绞痛患者参与了一项阿替洛尔（每日1次100毫克和200毫克，或每日2次100毫克）与普萘洛尔（每日2次80毫克）的双盲试验。记录了心绞痛发作次数（NAP）、无痛天数（NAFT）、舌下硝酸甘油消耗量（NNT）和自行车测力计数据（EFE）。与阿替洛尔和普萘洛尔的其他给药方案相比，每日2次给予100克阿替洛尔可显著减少NAP和NNT。然而，在上述任何治疗方案下，NAFT和EFE之间没有差异。仅每日2次给予100毫克阿替洛尔时，才有可能降低静息心率以及运动试验后即刻的心率，同时还能降低舒张压（静息、直立及应激试验后）。尽管其他人报道阿替洛尔的血浆半衰期较长（=24小时），但每日2次给药似乎是最有效的方案。得出的结论是，阿替洛尔（每日2次100毫克）比普萘洛尔（每日2次80毫克）具有更强的抗心绞痛作用。此外，阿替洛尔具有心脏选择性的优势。
