Mäkynen P, Karhumäki L, Seppänen S
Ann Clin Res. 1979 Apr;11(2):53-7.
Both atenolol 50 mg daily (A-50) and atenolol 100 mg daily (A-100) significantly reduced the angina attacks per week compared with placebo (p less than 0.05). Nitroglycerine consumption was less on A-50 (p less than 0.05) and on A-100 (p less than 0.025) than on placebo. There was no difference between the atenolol dosages in these respects. In comparison with placebo, atenolol gave a significant increase in total work performed until the appearance of 1 mm ST segment depression in bicycle exercise tests made between 3--4 p.m. (A-50: p less than 0.05; A-100: p less than 0.0017). The rate-pressure products (systolic BP X heart rate X 10(-2) at 6' at 30 W) was 163.5 +/- 12.5 (S.E.) on placebo. It diminished to 129.8 +/- 7.9 on A-50 (p less than 0.01) and to 113.9 +/- 6.6 on A-100 (p less than 0.001). The effect of A-100 on the rate-pressure product was stronger than that of A-50 (p less than 0.05). Relative heart volume did not change on A-50 compared with placebo but A-100 resulted in a slight enlargement of 22 ml/m2 BSA when compared to placebo (p less than 0.01). Side effects were minimal.
与安慰剂相比，每日服用50毫克阿替洛尔（A - 50）和每日服用100毫克阿替洛尔（A - 100）均显著减少每周心绞痛发作次数（p小于0.05）。A - 50（p小于0.05）和A -A - 100（p小于0.025）组的硝酸甘油消耗量均低于安慰剂组。在这些方面，阿替洛尔不同剂量之间无差异。与安慰剂相比，在下午3 - 4点进行的自行车运动试验中，直至出现1毫米ST段压低时，阿替洛尔显著增加了总做功量（A - 50：p小于0.05；A - 100：p小于0.0017）。安慰剂组在30瓦功率下6分钟时的速率 - 压力乘积（收缩压×心率×10⁻²）为163.5±12.5（标准误）。在A - 50组降至129.8±7.9（p小于0.01），在A - 100组降至113.9±6.6（p小于0.001）。A - 100对速率 - 压力乘积的作用强于A - 50（p小于0.05）。与安慰剂相比，A - 50组的相对心脏容积无变化，但与安慰剂相比，A - 100组导致每平方米体表面积轻微增大22毫升（p小于0.01）。副作用极小。
