核黄素与腺苷衍生物分子间复合物的晶体结构和分子结构
The crystal and molecular structure of an intermolecular complex between riboflavin and an adenosine derivative.
作者信息
Voet D, Rich A
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1151-6. doi: 10.1073/pnas.68.6.1151.
Abstract
Riboflavin and the adenosine derivative 5'-bromo-5'-deoxyadenosine form a crystalline 1:1 intermolecular complex, the structure of which has been solved by x-ray diffraction analysis. The adenine ring is found to be joined by two hydrogen bonds to the uracillike end of the riboflavin isoalloxazine ring. In addition, the riboflavin and the adenosine molecules associate through the formation of stacks of alternating parallel adenine and isoalloxazine rings. These intermolecular associations are considered to be models for intramolecular association in the coenzyme flavin adenine dinucleotide (FAD), which contains both adenosine and riboflavin.
摘要
核黄素与腺苷衍生物5'-溴-5'-脱氧腺苷形成一种晶体状的1:1分子间复合物，其结构已通过X射线衍射分析得以解析。发现腺嘌呤环通过两个氢键与核黄素异咯嗪环的尿嘧啶样末端相连。此外，核黄素和腺苷分子通过交替平行的腺嘌呤环和异咯嗪环形成堆积而缔合。这些分子间缔合被认为是含有腺苷和核黄素的辅酶黄素腺嘌呤二核苷酸（FAD）中分子内缔合的模型。
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