Kruchakova F A, Izabolinskaia R M, Polner R A
Vopr Med Khim. 1971 Jul-Aug;17(4):356-60.
Experiments were run on three groups of healthy guinea pigs. One group was given ethionamide, kanamycin and PASA another was given ethionamide, kanamycin and pyrazinamide while the third served as a control. These studies permitted to establish that the above drugs affect the activity of enzymes involved in the metabolism of carbohydrates and nucleic acids. Activity of glucose-6-phosphatase and aldolase significantly decreased in liver, brain and lung tissue. At the same time, activity of deoxyribonuclease and ribonuclease in the tissues concerned sharply increased. Changes in activity of phosphohexose isomerase, lactate dehydrogenase and aminotransferases in these tissues was statistically insignificant.
对三组健康豚鼠进行了实验。一组给予乙硫异烟胺、卡那霉素和对氨基水杨酸；另一组给予乙硫异烟胺、卡那霉素和吡嗪酰胺，而第三组作为对照。这些研究证实上述药物会影响参与碳水化合物和核酸代谢的酶的活性。肝、脑和肺组织中的葡萄糖-6-磷酸酶和醛缩酶活性显著降低。与此同时，相关组织中的脱氧核糖核酸酶和核糖核酸酶活性急剧增加。这些组织中磷酸己糖异构酶、乳酸脱氢酶和转氨酶活性的变化在统计学上不显著。
