赭曲霉毒素A对小鼠产生的血液学变化。

Hematological changes produced in mice by ochratoxin A.

作者信息

Gupta M, Bandopadhyay S, Paul B, Majumder S K

出版信息

Toxicology. 1979 Sep;14(1):95-8. doi: 10.1016/0300-483x(79)90095-7.

PMID:531904

Abstract

The effects of ochratoxin A (5 mg/kg, intraperitoneal) on clotting time, hemoglobin, total count of red blood cells and white blood cells and differential count of white blood cells were studied in mice. This mycotoxin caused a significant decrease in the hemoglobin level and in the total count of red blood cells. Among white blood cells there was a significant increase in small lymphocytes and a significant fall in the count of neutrophils, basophils and monocytes in treated mice. The administration of ochratoxin A also prolonged the clotting time by more than 6-fold.

摘要

研究了赭曲霉毒素A（5毫克/千克，腹腔注射）对小鼠凝血时间、血红蛋白、红细胞总数和白细胞总数以及白细胞分类计数的影响。这种霉菌毒素导致血红蛋白水平和红细胞总数显著降低。在处理过的小鼠中，白细胞中，小淋巴细胞显著增加，中性粒细胞、嗜碱性粒细胞和单核细胞计数显著下降。施用赭曲霉毒素A还使凝血时间延长了6倍多。