赭曲霉毒素A和桔霉素对小鼠产生的血液学变化。

Hematological changes produced in mice by ochratoxin A and citrinin.

作者信息

Gupta M, Sasmal D, Bandyopadhyay S, Bagchi G, Chatterjee T, Dey S

出版信息

Toxicology. 1983 Jan;26(1):55-62. doi: 10.1016/0300-483x(83)90056-2.

Abstract

The effect of 6 weekly injections of ochratoxin A (5 mg/kg) and citrinin (20 mg/kg) on the following hematological indices of mice was studied: erythrocyte sedimentation rate, hematocrit percentage, mean corpuscular values, red cell indices, platelet count, total count of bone marrow cells, differential count of bone marrow cells, total count of splenic cells, spleen weight, and serum calcium. These mycotoxins resulted in a significant decrease in platelet count and hematocrit values. On the other hand, they increased erythrocyte sedimentation rate, mean corpuscular values and red cell indices. Weight of the spleen and the splenic cell count decreased significantly in ochratoxin A and citrinin treated mice. Total count of bone marrow cells, erythrocyte precursors, leucocyte precursors and megakaryocyte precursors of femoral bone marrow decreased significantly in toxin treated mice. Calcium concentration in the serum of toxin treated mice also was decreased significantly.

摘要

研究了每周注射6次赭曲霉毒素A（5毫克/千克）和橘霉素（20毫克/千克）对小鼠以下血液学指标的影响：红细胞沉降率、血细胞比容百分比、平均细胞值、红细胞指数、血小板计数、骨髓细胞总数、骨髓细胞分类计数、脾细胞总数、脾脏重量和血清钙。这些霉菌毒素导致血小板计数和血细胞比容值显著降低。另一方面，它们增加了红细胞沉降率、平均细胞值和红细胞指数。在赭曲霉毒素A和橘霉素处理的小鼠中，脾脏重量和脾细胞计数显著下降。毒素处理小鼠的股骨骨髓细胞总数、红细胞前体、白细胞前体和巨核细胞前体显著减少。毒素处理小鼠血清中的钙浓度也显著降低。