尼日利亚北部扎里亚的脑膜炎球菌感染疫情。3. 脑膜炎球菌带菌情况

An epidemic of meningococcal infection at Zaria, Northern Nigeria. 3. Meningococcal carriage.

作者信息

Hassan-King M, Greenwood B M, Whittle H C, Abbott J D, Sutcliffe E M

出版信息

Trans R Soc Trop Med Hyg. 1979;73(5):567-73. doi: 10.1016/0035-9203(79)90054-3.

PMID:531911

Abstract

Meningococcal carriage was studied in household contacts of patients with group A meningococcal disease and in controls. The carriage rate of group A meningococci among 1,098 household contacts was low (3.8%) and only slightly higher than the carriage rate found among 416 controls (2.6%). However, higher carrier rates were found among those in close contact with a patient. Carriage was found most frequently among children and young adults and was commoner in adult females than in adult males. Sulphonamides had no effect on carriage and all 60 strains tested in vitro were resistant to sodium sulphadiazine at a concentration of 10 micrograms/ml.

摘要

对A群脑膜炎球菌病患者的家庭接触者及对照组进行了脑膜炎球菌带菌情况研究。1098名家庭接触者中A群脑膜炎球菌的带菌率较低（3.8%），仅略高于416名对照组中的带菌率（2.6%）。然而，与患者密切接触者的带菌率更高。带菌情况在儿童和年轻人中最为常见，成年女性比成年男性更常见。磺胺类药物对带菌情况无影响，体外测试的所有60株菌株对浓度为10微克/毫升的磺胺嘧啶钠均耐药。