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明尼苏达沙门氏菌和鼠伤寒沙门氏菌R菌株脂多糖结构的研究。

Studies on the structure of lipopolysaccharides of Salmonella minnesota and Salmonella typhimurium R strains.

作者信息

Sutherland I W, Lüderitz O, Westphal O

出版信息

Biochem J. 1965 Aug;96(2):439-48. doi: 10.1042/bj0960439.

DOI:10.1042/bj0960439
PMID:5320030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1207058/
Abstract
  1. The composition of the lipopolysaccharides and the corresponding lipid-free polysaccharides from four R-mutants of Salmonella has been studied. All the lipopolysaccharides, from RI and RII serotypes contained d-glucose, d-galactose, heptose, N-acetylglucosamine and 3-deoxy-2-oxo-octonate. The polysaccharide obtained from the RII lipopolysaccharides also contained all these sugars. The polysaccharides from RI lipopolysaccharides lacked N-acetylglucosamine. 2. From partial hydrolysates of the lipopolysaccharides, a number of oligosaccharides have been isolated and partially characterized. Oligosaccharides containing N-acetylglucosamine or glucosamine were obtained only from RII lipopolysaccharides. Several oligosaccharides composed of glucose and galactose were common to RI and RII preparations. 3. A structural unit, based on the oligosaccharides found, is proposed for the RII lipopolysaccharide. It contains the sequence: alpha-N-acetylglucosaminyl- alpha-glucosyl-alpha-galactosyl-glucosyl.... A second alpha-galactosyl residue is bound to position 6 of the last glucosyl group. The complete unit is believed to to be attached to a polyheptose phosphate backbone in the RII antigen. 4. The RI lipopolysaccharide of Salmonella minnesota contains an analogous structure lacking the terminal N-acetylglucosamine residue. 5. A basal structure common to the lipopolysaccharides of several Salmonella species is proposed.
摘要
  1. 对沙门氏菌四个R突变体的脂多糖及相应的去脂多糖的组成进行了研究。来自RI和RII血清型的所有脂多糖都含有d-葡萄糖、d-半乳糖、庚糖、N-乙酰葡糖胺和3-脱氧-2-氧代辛酸酯。从RII脂多糖获得的多糖也含有所有这些糖类。来自RI脂多糖的多糖缺乏N-乙酰葡糖胺。2. 从脂多糖的部分水解产物中，分离出了一些寡糖并对其进行了部分表征。仅从RII脂多糖中获得了含有N-乙酰葡糖胺或葡糖胺的寡糖。几种由葡萄糖和半乳糖组成的寡糖在RI和RII制剂中很常见。3. 根据所发现的寡糖，提出了RII脂多糖的一个结构单元。它包含以下序列：α-N-乙酰葡糖胺基-α-葡糖基-α-半乳糖基-葡糖基……第二个α-半乳糖基残基与最后一个葡糖基的6位相连。完整的单元被认为连接到RII抗原中的聚庚糖磷酸主链上。4. 明尼苏达沙门氏菌的RI脂多糖含有类似的结构，但缺少末端的N-乙酰葡糖胺残基。5. 提出了几种沙门氏菌物种脂多糖共有的基本结构。

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