沙门氏菌化学型VI O抗原的免疫化学。U群（o 43）沙门氏菌脂多糖中寡糖的结构。
The immunochemistry of Salmonella chemotype VI O-antigens. The structure of oligosaccharides from Salmonella group U (o 43) lipopolysaccharides.
作者信息
Lüderitz O, Simmons D A, Westphal G
出版信息
Biochem J. 1965 Dec;97(3):820-6. doi: 10.1042/bj0970820.
Abstract
- A series of oligosaccharides was isolated from Salmonella milwaukee lipopolysaccharide by partial acid hydrolysis. 2. Structural studies on these oligosaccharides indicated that the O-specific side chain of this lipopolysaccharide has a repeating pentasaccharide unit that is probably alpha-d-galactosyl-(1-->3)-beta-d-galactosyl- (1-->3)-N-acetylgalactosaminyl-(1-->3)-N-acetyl- d-glucosaminyl-(1-->4)-l-fucose. 3. Another oligosaccharide, which is not structurally related to the repeating pentasaccharide unit, has also been isolated and it is indistinguishable from an oligosaccharide obtained from Salmonella ;rough' (R) lipopolysaccharides. The isolation of this and similar core oligosaccharides from all chemotype VI lipopolysaccharides supports the view that Salmonella S-lipopolysaccharides have a common core that is probably identical with RII lipopolysaccharide.
摘要
- 通过部分酸水解从密尔沃基沙门氏菌脂多糖中分离出一系列低聚糖。2. 对这些低聚糖的结构研究表明，这种脂多糖的O-特异性侧链具有一个重复的五糖单元，其可能为α-d-半乳糖基-(1→3)-β-d-半乳糖基-(1→3)-N-乙酰半乳糖胺基-(1→3)-N-乙酰-d-葡糖胺基-(1→4)-l-岩藻糖。3. 另一种与重复五糖单元在结构上无关的低聚糖也已被分离出来，并且它与从沙门氏菌“粗糙”(R)脂多糖中获得的一种低聚糖无法区分。从所有化学型VI脂多糖中分离出这种及类似的核心低聚糖，支持了沙门氏菌S-脂多糖具有一个可能与RII脂多糖相同的共同核心的观点。
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