Bagramjan E R
Zentralbl Gynakol. 1979;101(17):1139-42.
Described in this paper is the relationship between chorionic gonadotrophin, placental lactogen, progesterone, oestradiol and oestriol in the blood of mother and embryo. The concentrations of human chorionic gonadotrophin (HCG) and human placental lactogen (HPL) in the mother's blood toward the full term of pregnancy were found to be between 300 and 800 times as high as those in foetal blood. No arteriovenous difference in concentration between the same hormones was recorded from the vessels of the umbilical cord. While the concentrations of progesterone, unconjugated oestriol, and total oestriol in the mother's blood were lower than those in foetal blood, the opposite was true for oestradiol which was lower in foetal blood. Clearly reduced levels of progesterone, unconjugated oestriol, and oestradiol but increased levels of total oestriol were recorded from the umbilical artery, as compared to the umbilical vein. The above findings are intended to encourage thinking about selective penetrability of the placenta, whenever hormone preparations are prescribed in advanced pregnancy.
本文描述了母亲和胚胎血液中绒毛膜促性腺激素、胎盘催乳素、孕酮、雌二醇和雌三醇之间的关系。发现母亲血液中人类绒毛膜促性腺激素（HCG）和人类胎盘催乳素（HPL）在妊娠足月时的浓度比胎儿血液中的浓度高300至800倍。从脐带血管中未记录到相同激素在动静脉之间的浓度差异。虽然母亲血液中孕酮、未结合雌三醇和总雌三醇的浓度低于胎儿血液中的浓度，但雌二醇的情况则相反，其在胎儿血液中的浓度较低。与脐静脉相比，脐动脉中记录到孕酮、未结合雌三醇和雌二醇的水平明显降低，但总雌三醇水平升高。上述发现旨在鼓励在晚期妊娠开激素制剂处方时，思考胎盘的选择性通透性。
