Reznik L V, Shakhmatova E I, Stopp M, Lavrova E A, Natochin Y V
Acta Biol Med Ger. 1979;38(8):1135-9.
During PAH excretion and 18 h after repeated PAH administrations to rats, renal cortical SDH activity was unchanged in comparison with untreated controls. On the other hand, 18 h after repeated administrations of 0.9% or 1.8% NaCl solution, SDH activity was decreased by about 20% in kidney cortex. In outer medulla SDH activity was decreased 18 h after all pretreatments. The decline of SDH activity was observed whenever an increased urinary Na excretion occurred, except that PAH was repeatedly administered. The probability is discussed that substrate-induced stimulation of the carrier system for weak organic acids is accompanied by an increase of mitochondrial activity in kidney cortex.
在大鼠进行对氨基马尿酸（PAH）排泄期间以及重复给予PAH 18小时后，与未处理的对照组相比，肾皮质的琥珀酸脱氢酶（SDH）活性没有变化。另一方面，在重复给予0.9%或1.8%氯化钠溶液18小时后，肾皮质的SDH活性降低了约20%。在外髓质中，所有预处理18小时后SDH活性均降低。无论何时出现尿钠排泄增加，都会观察到SDH活性下降，但重复给予PAH的情况除外。文中讨论了底物诱导的弱有机酸载体系统刺激可能伴随着肾皮质线粒体活性增加的可能性。
