Hjelm-Hansen M, Jørgensen K, Andersen A P, Lund C
Acta Radiol Oncol Radiat Phys Biol. 1979;18(5):385-407. doi: 10.3109/02841867909128225.
An analysis of 308 patients with carcinoma of the larynx was performed with respect to local recurrence and complications in relation to treatment level. The patients received primary irradiation with some difference in absorbed dose but with an equal fractionation schedule. Analysed in subgroups, correlations between local recurrence and treatment level were either demonstrated or strongly indicated. This is confirmed in a comparison with approximately 1 500 cases collected from the literature. Correlations between complications and treatment level were not found, but nevertheless indicated with respect to late edemas, which again are supported by comparison with approximately 800 cases collected from the literature. The risk of pharyngo-cutaneous fistula after total laryngectomy seems to be rather independent of irradiation level, although slightly dependent on field size. An optimum level of treatment has been estimated and brought into use since January 1978.
对308例喉癌患者进行了关于局部复发及与治疗水平相关并发症的分析。患者接受了初次放疗，吸收剂量有所不同，但分割方案相同。按亚组分析，局部复发与治疗水平之间的相关性得到了证实或强烈提示。与从文献中收集的约1500例病例进行比较，这一点得到了确认。未发现并发症与治疗水平之间的相关性，但对于晚期水肿有提示，与从文献中收集的约800例病例进行比较再次支持了这一点。全喉切除术后咽皮肤瘘的风险似乎相当独立于放疗水平，尽管略依赖于照射野大小。自1978年1月起，已估算并采用了最佳治疗水平。
