Hjelm-Hansen M
Acta Radiol Oncol. 1980;19(1):3-12. doi: 10.3109/02841868009130129.
Long term results, obtained in the treatment of 308 patients with laryngeal carcinoma are analysed with respect to local recurrence and complications. In this analysis the Cell Population Kinetic model, proposed by COHEN (1971) is used. The model for squamous cell carcinoma is found to be useful and in close agreement with observations of local recurrence, although a slight modification may be justified from the present data. No special model exists for late edema, but the model for late effects in the vascular stroma seems to be useful in this respect. Based on the model, a working hypothesis has been proposed, by which it is possible to predict the frequency of local recurrence and late edema. An optimum treatment schedule is calculated and converted to a split-course technique.
分析了308例喉癌患者治疗后的长期结果，包括局部复发和并发症情况。在该分析中，采用了科恩（1971年）提出的细胞群体动力学模型。鳞状细胞癌模型被证明是有用的，且与局部复发的观察结果密切相符，不过根据目前的数据，或许有理由进行轻微修改。对于晚期水肿不存在特殊模型，但血管基质的晚期效应模型在这方面似乎是有用的。基于该模型，提出了一个工作假设，据此有可能预测局部复发和晚期水肿的发生率。计算出了最佳治疗方案并转化为分割疗程技术。
